Wuhan University discovers the urine albumen is may renal pathological change " The arch-criminal "

Wuhan University discovers the urine albumen is may renal pathological change " The arch-criminal "
Wuhan University discovers the urine albumen is may renal pathological change " The arch-criminal "
Cable of July 5 of www.chinanews.com Wuhan (QiPing Wang HuaiMin Ai) One discovers recently, offered the target for the fact that clinical treatment and medicine of kidney trouble are developed to click in Wuhan University, have pointed out the direction. It is introduced, the medical circle thought, the proteinuria was the result that renal pathological change was produced in the past, found later a proteinuria patient accelerated renal fiber. Not only the expert is not merely resulted from renal pathological change according to urine albumen of this suspicion, but also it may be " arch-criminal " of the renal pathological change to have ,But been failing to find the direct evidence all the time. Moreover, the medical circle, to renal " poisons " to the urine albumen It is understood systematicly that the mechanism is scarce too. Wuhan University middle and southern hospital nephropathy internist Li XiaoNing discovers, protein kinase (C-delta) Express rising in the proteinuria, " murderer " who will induce the cell death of renal tubule as urine albumens . If restrain the expression in animal's kidney of proteinuria of protein kinase, the renal tubule that can succeed in inhibiting the proteinuria and induce is damaged. Researchers such as Li XiaoNing,etc. can find the proteinuria in the nephropathy level in the body and induce renal tubule cells to wither to die outside the body, and early characteristic incident and later period characteristic incident,etc. that found cells wither and die at the same time, thus from the cell level separately, inferior cell level, DNA level and protein level have verified the direct toxic function on renal tubule cells of albumin. In order to find treatment means, researchers such as Li XiaoNing,etc. transfer to the method to dye with chemical medicine and gene separately, the renal tubule succeeding in inhibiting the proteinuria and inducing is damaged. This result, it is at protein kinase gene strike except that proteinuria mouse models little in verify. These results indicate, scientists are expected to control the protein kinase level to prevent the renal tubule that the proteinuria cause from damaging through the medicine. Li would rather admit to the intersection of Wuhan University and doctoral candidate 2006 dawn, jointly train by medical college and Wuhan University, Georgia of U.S.A., this thesis is her research results during studying in U.S.A.. (End)


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