Bone-marrow transplantation will cure leukemia or step into " Little " Era Injure smaller The course is shortened Spend and reduce

Bone-marrow transplantation will cure leukemia or step into " Little " Era Injure smaller The course is shortened Spend and reduce
It is reported ' The red reporter of reporter and king Zhang Guoqing) In the near future, the bone-marrow transplantation treatment of leukemia or entering " high-efficient a little poisonous new era " : The preconditioning is to the patient's injury before bone marrow transplant " Small" ,The course of whole bone-marrow transplantation is obviously shortened, medical treatment spends reducing notably. 307 hospital blood head of the department Professor Ai HuiShengs of PLA man lead leukemia that the group carries on " Transplant a little " Study, obtain breakthrough progress, " half coincide hematopoietic stem cell, infuse, improve the intersection of old age and acute the intersection of marrow and cell leukemia curative effect " that preside over by it Study the thesis to issue on the academic magazine " blood " of international authority a few days ago, this is that the ambit scholar of blood disease of our country is in the third clinical thesis that issues of this magazine so far. At present, thesis of this research is chosen as 2011 by more than 2500 scientists of various countries from organizations such as Harvard University,etc. " It has a biological and medical thesis of scientific value most that in the world " . Ai HuiSheng says, " transplants a little " Can be called after the clear marrow is transplanted and the non- clear marrow is transplanted, the bone marrow transplant of leukemia is the second therapeutic revolution. At present, the clear marrow used extensively at home is transplanted and originated in fifty or sixty times of last century, this skill type will go on to the patient " Cause the fatal character " Preconditioning,last lymphocyte and bone marrow cell, the advantage is to realize well that supports the totally planting into of the normal hematopoietic stem cell of body, produce and implant and resist the leukemia effect (GVL) ,The intersection of shortcoming and quality pneumonia among being, infect,etc. implant, resist the intersection of owner and disease The relevant complication morbidity is high, up to 70%- 80%, is thought to belong to " high-efficient and hypertoxically " . Subsequently, the non- clear marrow treated leukemia to present in 1997, known as the first revolution of bone-marrow transplantation treatment of leukemia, namely remove lymphocyte totally in preconditioning, part remove the intersection of bone marrow and cell, therefore though GVHD reduces to some extent, the incidence is still up to about 30%, is thought to belong to " reduce the poison high-efficiently " . In " transplant a little " China, patient need preconditioning almost, need, accept, can kill leukemia and the intersection of tumour and chemotherapy of cell while being high-efficient only. Subsequently, the hematopoietic stem cell for the body to offer, through " enlarging " outside the body , reduce, input a patient behind the side effect receptor in the body, give play to " leader " through the normal hematopoietic stem cell Function, drive the leukaemia cell to carry on " gradual advancement reform " . The result reveals, the patient has not only produced better GVL but also scarcely present GVHD, so can be called " High-efficient and a little poisonous" . It is introduced, this research includes in 58 thes 80 -year-old acute marrow cell leukemia patient at the age of 60 altogether. Treat China in the tradition, the therapeutic response of the old age acute leukemia is bad, hematopoiesis inhibits long time, there are many complications, survival rate until 15%, and not obviously progressed in the past 20 years in 2. But is accepting " Transplant a little " After treating, the above-mentioned patient's leucocyte and blood platelet more simple chemotherapy group resume between 7 days and 10 days ahead of time, the serious infection rate is lowered to 26.7%, totally the relieving rate is up to 80%, the survival rate of the leukemia is raised to 38.9% in 2, and not seen GVHD,etc. transplant the relevant complication in all cases, this all domestic and foreign old leukemia up until now studies the best result being treated. Moreover, the patient can leave hospital in about 3 weeks in hospital treatment, so, it is only about 1/3 of the traditional bone-marrow transplantation method to treat the expenses. After the above-mentioned research project is finished, Ai HuiSheng,et al. has not coincided some patients who supported the body to carry on to 210 thed 88 year old, mankind leucocyte antigen 8 years old also " Transplant a little " Treat, cover acute marrow cell leukemia (AML) Wait for 6 kinds of blood diseases and some malignant tumour. Result reveal survival rate low to endanger the group to raise from 60% to 78.8%, mark and endanger the group to improve from 46% to 66.5%. Old AML ' From 60 years old to 88 years old) Improve relieving rate since 50% until 80%, there is no disease survival rate to improve to 38% from 15% 2 year totally. Ai HuiSheng says, clinical research has already verified " transplants a little " at present 6 year curative effect,and limit patient age and mixing type,family or having nothing to do not can employ without coinciding by personsing who supporting, this research has already obtained national natural fund key subject subsidy. But the next stage return need on " Transplant a little " Pathology, it is physiological mechanism and curative effects long-term further investigate when going on.

|