Measuring the bit of DNA foresees life-span? " science tells one's fortune " Guide and pay close attention to

Measuring the bit of DNA foresees life-span? " science tells one's fortune " Guide and pay close attention to
Measuring the bit of DNA foresees life-span? " science tells one's fortune " Guide and pay close attention to
Spain, British researcher find recently, draw the cells in the blood, test the length of the telomere in cells, can infer how long a person's life-span is. This kind of detection method will be listed on Britain at the end of 2011, therefore will attract dispute and concern It is the inventor of this commercial telomere detection method than Dr. Lasko that it is inferior that the telomere length determines the biological life-span Madrid state-run Mary of the cancer research center of Spain, she says this is a very simple, swift detection method, can analyze a lot of samples at one time. More important, can find the dangerous, very short telomere through measuring. The intersection of telomere and relation with life-span verify scientific research institute already, the intersection of Nobel and physiologic medical award of 2009 authorize, find three scientist of telomere. They find, the nucleus (DNA, call the chromosome) of people and some animals Both ends with cap for thing,be lasted telomered. The telomere is a kind of bit of DNA in fact, formed by special base array. The function of the telomere is to protect the chromosome, started, made and kept its function by telomere enzyme. The length of the telomere is determining the biological life-span, the shorter the telomere is, the shorter the biological life-span is. The activity of telomere enzyme adjusts and controls the old and feeble key factor. When people are young, the activity of telomere enzyme is relatively great, it is apt to keep and lengthen telomeres. But when old, the enzyme activity of the telomere is low, the length difficult to maintain the telomere, the telomere will be shortened, old and feeble will appear slowly. Moreover, discover too, the male telomere length is shortened and slightly faster than women, this is the reason why male mean age is lower than women too. Detection method leucocyte - chromosome - telomere say than the intersection of Lasko and Dr., people have many kinds of ages, for example, time the age, biological age and mental age. Some time of people age and biological age to have disparity, its individual difference can be up to 5-10 year old, it is even bigger. That is to say, the old and feeble possibility may postpone too ahead of time. The telomere length is a perfect display of the biological age, test the length of the telomere, from molecular biological level weighs the life-span. Having run a company named life length more than Lasko,et al., all test telomeres, foreseeing medical science and business activity of the life-span are taken charge of by this company. The concrete method is, the company cooperates with medical company of Europe including Britain, introduce the detection method to the market. Britain and medical company of Europe offer the blood specimen for life length company, then these blood specimens send to Madrid and pay testing. It is 500 European dollars (nearly to charge specifically shut 4620 yuan) . This expenses may be with testing the increase of the number of people will drop to some extent. Though has not explained more than Lasko what test, the concrete method can be known by the past research. Contain erythrocyte, leucocyte, blood platelet and some stem cells in the blood. Among them, the one that can reflect people's physiology and pathologic state most is the leucocyte, because there is chromosome within the leucocyte, the chromosome both ends certainly have telomeres. Existing finding, test the telomere on the chromosome of leucocyte, can infer the size of a person's life-span, still can find some clueses of disease at the same time, because the telomere relates to old and feeble and disease obviously. " science tells one's fortune " Do you have an interest? Measure another form that telomeres are actually genetic test, measure DNA of the embryo in order to judge whether the child has hereditary disease healthily and in the future before production like the pregnant woman, known as " Science tells one's fortune " . So, though open a business by the end of the year more than Lasko's company, already some people can test now when beginning to consult. After measuring telomeres, if you have a positive life style and attitude, it is known that one's own telomere is relatively short, will make good preparations for life ahead of time, comprising: First, it is shorter and unfavorable to remedy telomeres by many kinds of factors. The gene is only macrobiotic part of the reason, the function played is probably 25%-30%, longevity more factor acquired life style, reasonable meal, right amount of sport, give up smoking, stop drinking, psychology balanced, etc. So, the tester even the telomere is relatively short, can remedy by acquired life style. Second, the tester will do a more rational arrangement to one's own limited life length, may even do common people's impossible thing made. Third, the size of the telomere and morbidity of some diseases have relation. With the development of molecular biology, people may protect or lengthen the telomere length through the medical science method, prevent the production of old and feeble and disease. Certainly, will have a lot of people who will be unwilling to " tell one's fortune " too ,Think that if regards unknown thing as and knows to treat, will increase psychological burden, the life loses the meaning to a great extent. Moreover, it have many kinds of mechanisms that mankind and other biological one are old and feeble, the telomeres and telomere enzymes are only a kind of important route among them. People's old and feeble and life-span depends on the acquired life style, and the life style is the set of many kinds of factors. So, find that though there is scientific evidence in life-span according to the size of the telomere, but may not be totally accurate. Extend, read telomere, it tests to be to follow one's bent ethics problem to be difficult to it avoids most great problems that telomeres tests to be a common problem not faced since human genome study, ethics problem that the gene tests. In actual life, everybody's genes all have certain defect, and genetic defect, especially the person who has genetic defect of hereditary disease will probably be discriminated against in the modern society. Because after the genetic test information of the person who has genetic defect of hereditary disease is let out, will be very unfavorable to surviving, usually display in two respects, first, may be discriminated against while obtaining employment, second, will be received in social insurance and business insurance differently and treated. So, the Human Genome Project of 1990 (HGP) While implementing, include a stature plan, the ethics, law and social influence called HGP are studied (ELSI) ,The goal is to predict, consider impact on individual, the society and consequence of the Human Genome Project, concentrate on 4 fields: (1)While utilizing and explaining hereditary information, how to protect personal secrets, reach justly; (2)When new genetic technology applies to clinically, how to deal with the problem of agreeing etc. in the know; (3)For participating in the human experimenters of gene studies, how to make sure in the know to agree, protect the individual privacy; (4)Education of the public and professional personnel. Hereafter, UNESCO specially established " international biological ethics committee " composed of scientist, ethicist and experts from all walks of life . Pass in 3 to discuss, revise repeatedly, " about human genome and human right that draft International declaration " ,Abbreviated as " human genome declaration " ,There are four basic principles: Human dignity and equal, the scientist's research is free, human harmony and international cooperation. UNESCO thinks, the application of the Human Genome Project and genetic knowledge should not cause the injury to patient, party, experimenter and persons who are correlated with of interests, should be favorable to them, should weigh the terrible gain and loss while existing in advantages and disadvantages, compensate for the damage caused. So, the genetic test including that the telomere tests should be in " human genome declaration " Frame in go on,life length Company after the medical organization tests telomeres about people, must keep secret strictly in measuring the result, is damaged in order to discriminating against, legitimate rights and interests of the persons who avoid being examined. In addition, some researchers are afraid too the telomere detection method will be utilized, for example, on the grounds of test result of the telomere, promote some unchecked anti-aging medicine and other alive for evermore prescriptions. In this case, the telomere tests it is not a kind of behavior of following one's bent. Chain sport, can prevent telomere from shorten Wistar of U.S.A. Philadelphia the intersection of research institute and genetic the intersection of expert and angstroms of the intersection of horse and Niue Island Sri Lankan test Damien draw the intersection of department and Sri Lankan,et al., have measured the length of chromosome telomere in distance runner and often player's leucocyte, and the intersection of amount of exercise and very little telomere of person act as comparative analysis telomere and the same age bracket, healthy smoking never of them. Found finally, loved the player for being longer than not to love the player's telomere length of leucocyte chromosome, the enzyme activity of the telomere is higher, this can explain why like players for being more long-lived, this and physiologic or medical result of study that rewards to the winner of Nobel of 2009 is identical. Sri Lankan test Damien draw the intersection of department and research of Sri Lankan,et al., too can explain people old and feeble and ill in another perspective. For example, with the years, the probability that people suffer from cancer increases, the telomere that one of the reasons is the leucocyte is shortened, it is old and feeble to cause oneself. Leucocyte immune cell of whole body, naturally can't resist unusual cell such as growth of cancer cell effectively after being old and feeble. And sports can prevent the chromosome telomere in the leucocyte from shortening, maintain normal immunological function of the leucocyte, resist cancer. The same explanation is suitable for heart disease too. Under many kinds of factor function such as hypertension, the aging leucocyte will make the blood platelet build up with higher speed. Strengthen the young state that sports can keep the leucocyte, remove the blood platelet to build up effectively, prevent the emergence of diseases such as thrombus, myocardium infarction and hypertension,etc.. Another research of U.S.A. is to prove directly shorter life-span of telomeres is relatively short too even more. The researchers of University of California, Los Angeles were sponsored by national health research institute of U.S.A. " MacArthur's health studies old age " The project, has measured 236 blood samples of old volunteer of health at the age of 70-79. Found finally, in the male volunteer, the mortality that the telomere shortened the fastest one was 3 times of other people's. But for women volunteer, the telomere shortens the speed to have a little effect on mortality. It is determined that the factor of more important life-span is the initial telomere length, begin the short person of telomeres, mortality is 2.3 times of other people's.


|