The Hans coronary heart disease exchange genetic location of the sense order find newly

The Hans coronary heart disease exchange genetic location of the sense order, find newly
The Hans coronary heart disease exchange genetic location of the sense order, find newly
It is reported ' Reporter Wang Dan) Recently, world burn the intersection of name and academic periodical " natural heredity " issue king, scientist of Chinese, hold up research thesis written to wait for someone online. This research uses the related analytical method of the whole genome, finding coronary heart disease different from white race exchanges the genetic location of the sense and clicks in the crowd of the Han nationality of Chinese for the first time, this genetic location clicks and makes a variation the risk of suffering from coronary heart disease of the person who carries than 50% higher of ordinary people. Coronary heart disease is a kind of complicated disease caused by heredity, environmental factor and interaction, have certain families. The related analysis of the whole genome is to employ 500,000~100 ten thousand hereditary variation that can cover the human complete genome to scan the whole genome to a crowd, contrast related to study through big case of sample and then, sift, check, influence human property or the intersection of complexity and disease exchange the intersection of sense and method of gene. According to the introduction of this thesis first author, heart professor of internal medicine He Qing of BJ Hospital of Ministry of Public Health, studying the group is ordered several dozen medical scientific research institutions such as human genetic research center and this institute of the institute to make up by the scientific and technological university students of Central China. Since 2006, researchers gauged over 7000 Chinese the Han nationality crowd's samples, the crowd covers 5 cities such as Beijing, Wuhan, Harbin. Study the first discovery, on chromosome of the 6th of human genome, the location genotype of risk,etc. that the serial number is lighted for 6p24.1 genetic location relates to dropping in c6orfl05 gene expression, thus influence its downstream gene to participate in the morbidity mechanism of coronary heart disease. The statistics show, in the crowd of the Han nationality, it is about 5% to have this coronary heart disease to exchange the number of people clicked in genetic location of the sense. Qing He say, at present, report overth the intersection of application and the whole the intersection of genome and coronary heart disease that related analytical method find exchange the genetic location of the sense to order already in the world, but the great majority are the research which is based on the American-European continent crowd. Finding this time to the intersection of Chinese and diagnosis, treat, crowd of coronary heart disease, new medicine research and develop, may offer new target order.


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