It is no longer a dream to keep alive the fervour of youth The scientist can not research and develop old " Elixir of life "

It is no longer a dream to keep alive the fervour of youth The scientist can not research and develop old " Elixir of life "
It is no longer a dream to keep alive the fervour of youth The scientist can not research and develop old " Elixir of life "
Peter Pan on the dream island is young forever age. In actual life, some scientists are trying every means to formulate " elixir of life " letting people keep alive the fervour of youth too ,And concern directly the telomere of human body's old and feeble process becomes their key goal. " find " the magazine report according to U.S.A., first tablet taking telomere as target has already been listed on U.S.A., but is selling as the nutritional supplement at present. The manufacturer T.A. scientific companies of medicine say, they will refer the relevant research thesis to the counterpart soon, by examining the real efficiency of this kind of nutritional supplement strictly. Other drugmakers are stepping up one's own research and development step too, and estimate the medicine with function of slowing aging can get American Food and Drug Administration (FDA) within 15 years Approval. The anti-aging medicine is much-anticipated The telomere is DNA (DNA) lying in terminal chromosome Repeat arrays, there is protection of the telomere, the terminal chromosome would not be repaired the mechanism by cells to think by mistake it is DNA chip but repair automatically. Nobel Prize for physiology or medical science in 2009 is awarded to 3 American scientists, how in order to cite them " to discover telomere and telomere enzyme to protect chromosome " . The telomere will be shortened gradually with constant division of cells, when can't be shorter that it is as short as, cell stop, split just, to wear out and die final step. The mechanism that biologists have been attempting to shorten through blocking telomeres all the time controls human body's old and feeble process. The length of the telomere is maintained by the activity of telomere enzyme, but telomere enzyme only exists in human stem cell, reproduction cell, immune cell and malignant cancer cell, telomere enzyme in other adult's cells is usually in " Close " State. In 2001, the outstanding dragon's biological pharmaceuticals of U.S.A. of biotechnology giant isolated a molecule which was called TA-65 from herbal Radix Astragali, and claim it can strengthen the activity of telomere enzyme. But this function mechanism carry on assessment in research that has evaluate by counterpart. Outstanding the intersection of dragon and their product issued to New York scientific Company, T.A. of pharmaceutical manufacturer, biological pharmaceuticals, the latter will purify, concentrate from TA-65 molecule that is drawn in Radix Astragali, develop and become a kind of nutritional supplement, this is because the medicine needs after FDA authorize introducing to the market. Since 2007, first TA-65 nutrition supplement tablet taking telomere as target can be bought from doctor. T.A. scientific company says, TA-65 tablets can improve bone density and immune ability of the human body, as to having certain function with the old and feeble and relevant biological mark thing too, the person who has taken this kind of tablet says, their sport, vision and cognitive ability are strengthened to some extent. This CEOs of company Noel and Parton say, he himself has been already taking this kind of nutritional supplement for two years in succession, and all staff over 40 of this company are taking. In order to provide strong scientific support for these efficiency of claiming, T.A. scientific company plans to refer their research to the counterpart and review within this year. Wait for discussion result come out, will know dollar of marked prices let people spend wrong money one year such as tablet such as TA-65. Though T.A. scientific company can't propagate this kind of tablet and have curative effect of curing the disease, but, this company is testing TA-65 molecule since 2002, and claim firmly researchers have already found the connection between telomere length and a certain and old and feeble and relevant disease, also announced a result against old and feeble test on company's websites at the same time. Its rival, west Aila scientific company lying in Nevada state are developing and activating telomere enzyme in order to help to maintain medicines of the telomere length too, and hope to have relevant medicines to get approval of FDA one within 15 years. CEOs of company Bill and Andrews say: "35 kinds of compounds can open the telomere enzyme gene in our laboratory. " The carcinogenic risk can be ignored, there is not a free lunch all over the world. Aiming at delaying aging telomere enzyme may increase the probability which suffers from cancer to activate the treatment too. Research shows, promote little mouse's activity of telomere enzyme in the body, will make them suffer from skin carcinoma and breast cancer more easily. Andrews admits too, has some unknown risks to take the products that can activate telomere enzyme. Telomere enzyme can prevent the cancer cell from wearing out too, so TA-65 molecule will possibly help those cancer cells that should die to continue surviving. But Andrews points out, primary function of telomere enzyme activator is the length which keeps all telomeres at the same time, this has reduced the probability of the cell canceration in fact. In addition, telomere enzyme will keep resisting the activity of the immune cells of the cancer cell too, make their fighting capacity more lasting. The outstanding dragon's biological pharmaceuticals is developing a kind of independent telomere anticancer treatment at present, hope to kill the cancer cell through a kind of telomere enzyme inhibitor, make health cells safe and sound at the same time. This kind of compound is in the first stage of clinical trial at present, the second stage of clinical trial has already been scheduled to begin this year too. Regard telomere as whom target go on slow aging another difficult problem faced in research is, there is not appropriate model organism that can be used for drug test. The mankind always goes gradually through the shortening constantly of the telomere, but the animal is not like this, the mouse or monkey does not have a similar aging mechanism of telomere, so, the best drug test system can only be mankind itself. Unwilling to make the dangerous person with the body to those, researchers propose, the life style of keeping fit contributes to optimizing the activity of telomere enzyme too, and smoked, waited for the factors to all cause telomeres to lack even more than the average length fatly and for a long time.


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