The Hans exchange the sense gene and is found in lupus erythematosus

The Hans exchange the sense gene and is found in lupus erythematosus
The Hans exchange the sense gene and is found in lupus erythematosus
It is reported ' Reporter Feng LiZhong) Chinese scientist passes the research to lupus erythematosus patients of more than 12000 the Han nationality and persons who contrast healthily, have found 5 the Hans exchange the sense gene in lupus erythematosus, and confirmed 4 and exchanged induction to click. This research adopts the related analytical method of the whole genome to go on, develop prewarning, clinical diagnosis and new medicine of lupus erythematosus and have great meanings. On October 18, issued this research results online for the internationally famous academic periodical " natural heredity ". It is introduced, this research is jointly finished by 17 units such as the first affiliated hospital, southern research centers, Fudan University Huashan hospitals of national human genome of medical university in Anhui, the case sample used comes from more than 40 hospitals of the whole country. The research is a related biggest research project of the sample amount while analysing and researching of the whole genome of lupus erythematosus in the world at present. The researcher, through carrying on research to the lupus erythematosus patients of more than 12000 China the Han nationality and person who contrasts health, the ones that have found 5 have illness coming on and is closely related with with the Han nationality crowd have exchanged the sense gene: ETS1, IKZF1, RASGRP3, SLC15A4 and TNIP1, have and confirmed 4 new exchanging the induction to click. Study, prove, go out of the intersection of European and 7 that philtrum find exchange sense gene philtrum store in likewise in the Han nationality at the same time. It proves, the dangerous factor of heredity that lupus erythematosus has illness coming on in the mechanism has the same and different exchanging the sense gene among different ethnic groups that the research is studied through science of heredity for the first time. According to the introduction of expert, this research results make the mankind have deeper understanding on morbidity mechanism of lupus erythematosus, can offer help to the prevention and cure of disease. For example, somebody measures and carries the dangerous genotype, can pass and avoid the dangerous environmental factor, reduce the risk of taking place in disease; To the intersection of lupus erythematosus and patient, can carry on specificity, treatment of individual according to genotype, thus reduce the therapeutic side effect and reduce and treat the expenses, raise life quality. It chains the whole genome to be to accompany by the whole a that genome plan rise, search and determine complicated disease exchange the intersection of sense and method of gene in related analytical method. In a short period of 3 after this kind of method appeared, found more than 500 of great common disease and common property for 100 multi-type and exchanged sense gene in the world. But the research is mainly finished by countries such as U.S.A., Great Britain,etc., and is directed primarily to the European crowd.


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