Taking sulfa drugs should pay attention to 5 taboos

Taking sulfa drugs should pay attention to 5 taboos
Taking sulfa drugs should pay attention to 5 taboos
Sulfa drugs is antimicrobial of the artificial synthesis initially, though have been replaced on clinic by a lot of new antibiotic medicines at present, but because sulfa drugs, to some infective diseases (such as epidemic encephalitis, plague) There is better curative effect, and there are such advantages as properties are steady, cheap easy to use, so still occupy certain position in the anti-infectious medicine. But should pay attention to the following several points while taking sulfa drugs: 1. The main indication of mastering indication sulfa drug is epidemic encephalitis, various infection due to fungus dysentery, enteritis, plague and dissolving courageous and upright streptococcus, pneumonia coccus, golden yellow staphylococcus, Escherichia coli, bacillus out of shape,etc., can prevent epidemic encephalitis and rheumatic fever. But invalid to viral disease, for instance angina, swallowing aching and upper airway infection,etc.. Can't take sulfa drug to the unidentified generating heat of reason either, so as not to delay diagnosing and treating. Meanwhile, sulfa drug is used some time later, will produce and is able to bear nature, is able to bear the production of nature, all sulfa drugs will fail, should change and use other antibacterial medicines rapidly at this moment. 2.Consumption want, stress, use sulfanilamide medicine first pharmaceutical should, by achieving the goal of restraining the fungus rapidly, then use the keeping amount (namely normal quantity) ,After disappearing in symptom, offer a small amount of the most 2- 3 times finally. In order to keep the fairly long drug effect, prevent the bacterium from rebounding. Can't strengthen and spend medicine quantity to make sure to keep in mind arbitrarily use medicine, the number of times that increase and use medicine or lengthening the course of treatment, in case the medicine is accumulated and poisoned. 3.Matching wants rational and hydrogen sodium and clothes carbonic acid: The intersection of supersession and the intersection of product and the intersection of acetyl and sulfanilamide of sulfa drugs solubility low and easy to appear crystallization in leaning towards sour urine, it but lay solubility at environments alkaline rise, so, for a long time or heavy dose of at not taking by sulfa drugs, the patient can also add equal amount of hydrogen sodium carbonic acid (sodium bicarbonate) besides drinking more water It is the same as the clothes, used for alkalizing the urine, improve the solubility in the urine of acetyl sulfanilamide, increase the excretion amount of acetyl sulfanilamide, reduce the forming of the crystalline urine. Not with acid medicine and clothes: Some acid medicine such as chlorpromazine hydrochloride, hydrochloric acid aureomycin, vitamin C, chlorine ammonium, peptic mixture, ipecacuanha mixture,etc., should not share with sulfa drugs, because of very acidifying urine of these medicines, make the solubility in the urine of supersession product acetyl sulfanilamide of sulfa drugs reduce and precipitate to get crystallization, produce crystalline urine but damage kidney. Sulfa drug especially compound supplementary potentiating sulfanilamide preparation, can't be with compatibilities such as many kinds of medicines such as penicillin, tetracycline, hydrogen sodium carbonic acid, chlorine calcium, chlorpromazine, vitamin C, vitamin B1, compound sodium chloride solution,etc., must use alone. 4.It is apt to cause a grain of cell reducing, reducing and regenerated obstacle anaemia of the blood platelet to watch out for sulfa drugs of side effect, should check the blood around and like the change while using medicine regularly; The liver is damaged, can cause jaundice, liver function to fail, liver necrosis can happen in the serious one, need to determine liver function while using medicine regularly, the hepatopathy patient should avoid using this kind of medicine; Kidney damage, should monitor renal function use medicine, renal function fail, desiccate and shock and old patient employ the easy to aggravate or appear the kidney damage medicine, should avoid using; Because the sulfanilamide medicine can make a few patients present spiritual symptoms such as dizzy, having a headache, weak, dispirited and insomnia,etc., so, during using medicine, should not be engaged in the high altitude work and drive; The allergic response is seen more, and can be shown as serious exudative many shape erythema, poisoning epidermis necrosis and loosening drug rash,etc., so allergic physique and patient with allergic history should try hard to avoid using this kind of medicine. 5.Detail ignore have some sulfa drug, solubility very small in urine, for increase solubility its, must take the sodium bicarbonate one at the same time, make the urine alkaline; Secondly, advise patients and drink more water, increase the urine amount, by reducing the medicine density in the urine. Drink a large amount of water, urine quantity little, the medicine is dense in the urine, it is easy to precipitate to get sulfanilamide crystallization in places such as renal tubule, renal pelvis, ureter, bladder,etc., produce machinery to stimulate the kidney, cause pain in the back, hematuria, even urine retention,etc. happens. So patient must drink the water more, urine quantity no less than 1.5 liters every day. Disgusting, vomiting, appetite failing and stomachache,etc. takes place and react to take the regular meeting on an empty stomach, can lighten it and stimulate function to swallow after a meal or with the thin rice gruel. The sulfanilamide medicine can inhibit B clan vitamin in the enteric formation inside, so, the person who uses sulfanilamide medicines more than one week, should offer thiamine in order to prevent it scarcely at the same time. The person who has sulfanilamide drug allergy, the huge young cell anaemia patient should forbid using. Pregnant woman, women breast-feeding their children should avoid using. The baby fewer than two months belongs to and absolutely forbids the range too. The old patient should avoid using, if really there is indication, must employ after weighing the advantage and disadvantages.


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