Treat systemic lupus erythematosus or have new routes

Treat systemic lupus erythematosus or have new routes
Treat systemic lupus erythematosus or have new routes
Treat systemic lupus erythematosus or have new routes
It is reported ' Reporter Sun GuoGen) Fudan University immuno-biology research institute and biomedical bear of research institute of Suzhou university think in the seminar which the east professor headed, discover, can there is one kind one kind of albumen P compositions (SAP albumen) of starch of important serum in combination with DNA normally in human serum through 12 years ,And put forward SAP albumen for the first time and have function which treats the systemic lupus erythematosus. Systemic lupus erythematosus influences crowd's most extensive, most serious one's own immunity to be ill, patient finally many because organ function depleted death, morbidity its 35/10 Wan, our country is up to 75/10 Wan. Though until treatment means progress, lupus nephritis victim survival rate already improvement to 82% present from 44% of will it be the fifties the 20th century 5 year, but the average life span is only 44 years old. Systemic the intersection of lupus erythematosus and clinical manifestation and have illness coming on mechanism to be extremely complicated, still have a lot of unidentifieds, bring the great difficulty for the clinical specific treatment to the cause of disease. Discern, reply and intervene 3 key problems of countermeasure in bear's one's own immunity that the east seminar catches the systemic lupus erythematosus of thinking, the 12 - year at the beginning one is overall tests to study. Xiong SiDong waits in animal's research in early days, injects the little mouse by a large number of DNA activating the cell source by oneself, find little mouse can produce typical the intersection of lupus and symptom, including being produce, cause lupus patient death lupus nature nephritis one of the main reasons finally. So, activate DNA of the cell source in the human body, it may be the important cause of disease of leading to the fact systemic lupus erythematosus takes place. SAP albumen existing in human serum can combine DNA, can then this kind of SAP protein treat systemic lupus erythematosus? In go on, find analyze, to a large number of the intersection of lupus and patient and the intersection of lupus and little the intersection of mouse and the intersection of serum and index SiDong Xiong,etc., lupus patient and lupus little the intersection of mouse and SAP in the body albumen produce competence to be obviously enough, until disease supplement the intersection of SAP and albumen, can prevent from lupus include the intersection of lupus and emergence of nephritis,etc. effectively early period, if supplement SAP albumen in the serious one of disease, can obviously reduce the organization of the little mouse of lupus to destroy and lighten nephritis symptom. Study yet to find, little mouse's lupus nephritis has a large number of pathogenic macrophages to assemble while organizing, may lead to the fact main reason that nephritis take place one of, give little the intersection of mouse and kidney supplement SAP behind the albumen, inferior group of pathogenic macrophage is obviously reduced, the substitute is presented a large number of inferior group of macrophage with protective actions. The intersection of research and relevant thesis this issue immunity learn proceedings " amynologic magazine " and international periodical at " whether public the intersection of science and library synthesize " in U.S.A. in succession. " natural rheumatism learns to summarize " the foreign expert of special publication comments " the newest one, think this research has opened up the new route in order to treat systemic lupus erythematosus.



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