Treating chronic lung worry has new targets that is clicked

Treating chronic lung worry has new targets that is clicked
Treating chronic lung worry has new targets that is clicked
Treating chronic lung worry has new targets that is clicked
It is reported ' Special correspondent Li XiaoSui) Recently, " chlorine ionophore function and mechanism's research of adjustment in the hypoxia artery high pressure of lung " that are presided over by the flourishing professor of the king of the Guangxi Zhuang Autonomous Region Gui Lin medical college, have pointed out the chlorine ionophore and blocked three benzene oxygen ammonia of pharmaceutical from new theory and experiment basis, hydroxyphenylaminopropionic acid protein inhibitor Mongolian oak skin plain can reduce the artery high pressure of lung by the intersection of traditional Chinese medicine and white the intersection of Radix Aconiti Lateralis Preparata and the intersection of extract and the intersection of brain and the intersection of glucoside and lipoproteining, treating chronic lung source heart disease for pertinence finds the new target to click. It is reported, the pathological change foundation that chronic lung worry has illness coming on is the hypoxia artery high pressure of lung, its characteristic of change is that the lung blood vessel shrinks and rebuilds with the blood vessel structure of lung. Function in order to explore the chlorine ionophore has illness coming on in the hypoxia lung artery in the mechanism under high pressure, the intersection of hydroxyphenylaminopropionic acid and the intersection of protein and the intersection of kinase and the intersection of signal and thorough fare and hypoxia the intersection of lung and the intersection of artery and relation of high pressure, and whether growth factor conducts the thorough fare to adjust and control the expressing and promoting cell hyperplasia,etc. of the chlorine passway through the receptor hydroxyphenylaminopropionic acid protein kinase signal in lung artery smooth muscle cell hyperplasia, king's flourishing seminar adopts the physiological technology of pincers electricity of the diaphragm to combine the technology of molecular biology, canvass constantly in the experiment from the intersection of cell and the intersection of molecule and level and whole animal, prove chronic hypoxia make lung the chlorine passway electric current that calcium is being activated increase at the artery smooth muscle cell membrane for the first time; The chlorine passway can adjust and control lung artery cell shrinking, hyperplasia, wither and dying of smooth muscle, play an important role in the hypoxia lung artery has illness coming on under high pressure; The hydroxyphenylaminopropionic acid protein kinase signal thorough fare participates in the artery smooth muscle cell hyperplasia of lung, withers to die through adjusting and controlling the expression of the chlorine passway; Chlorine ionophore block pharmaceutical three the intersection of benzene and the intersection of oxygen and ammonia, the intersection of hydroxyphenylaminopropionic acid and the intersection of protein and the intersection of kinase and the intersection of inhibitor and the intersection of Mongolian oak and skin, can reduce the intersection of oxygen deficiency due to and big the intersection of mouse and the intersection of lung and arterial pressure, rise while being plain, improve the right ventricle plumply and it is increased thick, obviously treat function on the hypoxia lung artery under high pressure that the lung is arteriolar; The lipoprotein of glucoside of brain can inhibit the passway electric current of chlorine on the lung artery smooth muscle cell membrane, have medicines of potential clinical using value in the hypoxia high-pressure treatment of lung artery very much.



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