Hepatocarcinoma jointly set the treatment free with the gene later period cure

Hepatocarcinoma jointly set the treatment free with the gene later period cure,
Hepatocarcinoma jointly set the treatment free with the gene later period cure,
Hepatocarcinoma jointly set the treatment free with the gene later period cure,
It is reported third army medical university large the intersection of level ground and the intersection of hospital and the intersection of field operations and surgical the intersection of research institute and the intersection of tumour and Wang Dong Professor and seminar of him, director of centre, pass, study 18, create, unite the method later period hepatocarcinoma while treating by the gene, radiotherapy, make curative effect rise to 85% from 70%. Recently, the research obtained the second prize of the medical prize of achievements of the army. In 1992, when Wang Dong studied for the doctorate, were devoted to the research of gene therapy cancer. He finds and verifies in the basic research, tumour knows the gene adjusts and controls the most important and key molecule in the network at present to inhibits genetic P53, prove on the basis of hepatocarcinoma of gene therapy, improves notably radiotherapy sensitiveness through animal's experiment. His seminar has taken the lead in setting up microwave and repairing the immune group method at home, have briefed on P53 gene to change the important characteristic of liver cell cancer through molecule epidemiology, divide 249 peculiar mutation and the intersection of mutation and two type of sending out etc., son of password, into the intersection of P53 and gene mutation clearly, have proposed the aflatoxin B1 mainly causes P53 peculiar type sudden change, and the B-mode hepatitis virus is infected with the view playing a main role in P53 distributing sudden change. Prove rAd-P53 through internal and external experiments of body ' Recombinate the wild type P53 adenovirus) Unite the radiotherapy sensitiveness that radiotherapy can improve the liver cancer cell notably, and curative effect is higher than single gene therapy and single radiotherapy. In 2004, Wang Dong seminar jointly treated the gene, radiotherapy the hepatocarcinoma method was applied to clinic. The intersection of hepatocarcinoma and contrast treat, observe, study, indicate rAd-P53 unite radiotherapy treat hepatocarcinoma to be safe and effective later period through being several hundred case clinical, tolerance is good, can change the big hepatocarcinoma not excised into the potential advantage of the small hepatocarcinoma that can excise, especially suitable for later period or difficult to tolerate and refuse the hepatocarcinoma patient of surgery treatment. (Zou fights for Zhu GuangPing in spring)



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